Page last updated: 2024-12-09

1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone is a **small molecule** with the chemical formula C₁₇H₁₆N₄OS. Its importance in research stems from its potential as a **pharmacological tool** and **therapeutic agent**.

Here's why it's important for research:

* **Target Specificity:** The molecule targets the **5-HT₆ receptor**. This receptor is a serotonin receptor subtype involved in various physiological processes, including cognition, sleep, and anxiety.
* **Therapeutic Potential:** By targeting the 5-HT₆ receptor, 1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone holds promise for treating conditions like:
* **Alzheimer's disease:** The 5-HT₆ receptor is implicated in cognitive impairment and memory loss.
* **Anxiety disorders:** Modulating 5-HT₆ activity may be helpful in managing anxiety.
* **Sleep disorders:** The 5-HT₆ receptor is involved in sleep regulation.
* **Research Tool:** The molecule can be used as a **tool compound** in research to investigate the role of the 5-HT₆ receptor in various biological processes and disease states.

**Current Research:**

Scientists are actively studying 1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone and related compounds for their potential as therapeutic agents for the conditions mentioned above. Research is ongoing to understand the molecule's pharmacokinetic properties, efficacy in preclinical models, and safety profile.

**Important Notes:**

* It's crucial to note that while this molecule shows promise, it's still in the **early stages of research**. It has not yet been approved for clinical use.
* Research on 1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone and its derivatives is ongoing, and further investigations are needed to fully understand its potential therapeutic benefits and risks.

In summary, 1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone is a molecule with potential applications in drug development for treating various conditions, thanks to its ability to target the 5-HT₆ receptor. However, more research is necessary before it can be considered a viable therapeutic option.

Cross-References

ID SourceID
PubMed CID900714
CHEMBL ID1535147
CHEBI ID111198

Synonyms (15)

Synonym
2-{[4-(2-pyridinyl)-1-piperazinyl]carbonyl}-1,3-benzothiazole
smr000075437
MLS000063704 ,
1,3-benzothiazol-2-yl[4-(pyridin-2-yl)piperazin-1-yl]methanone
STK155495
CHEBI:111198
AKOS000603465
1,3-benzothiazol-2-yl-(4-pyridin-2-ylpiperazin-1-yl)methanone
HMS2334P08
1,3-benzothiazol-2-yl-[4-(2-pyridyl)piperazino]methanone
bdbm33598
1,3-benzothiazol-2-yl-[4-(2-pyridinyl)-1-piperazinyl]methanone
cid_900714
CHEMBL1535147
Q27190811
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
piperazines
pyridinesAny organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (12)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Beta-lactamaseEscherichia coli K-12Potency100.00000.044717.8581100.0000AID485294
Chain A, HADH2 proteinHomo sapiens (human)Potency39.81070.025120.237639.8107AID886
Chain B, HADH2 proteinHomo sapiens (human)Potency39.81070.025120.237639.8107AID886
LuciferasePhotinus pyralis (common eastern firefly)Potency23.93410.007215.758889.3584AID588342
glp-1 receptor, partialHomo sapiens (human)Potency7.07950.01846.806014.1254AID624172
ATAD5 protein, partialHomo sapiens (human)Potency21.85280.004110.890331.5287AID504466; AID504467
TDP1 proteinHomo sapiens (human)Potency23.10930.000811.382244.6684AID686978; AID686979
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.81070.011212.4002100.0000AID1030
thyroid stimulating hormone receptorHomo sapiens (human)Potency31.62280.001318.074339.8107AID926; AID938
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency9.20000.00419.984825.9290AID504444
VprHuman immunodeficiency virus 1Potency63.09571.584919.626463.0957AID651644
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
prothrombinHomo sapiens (human)IC50 (µMol)50.00000.00103.317014.6895AID1215
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]